Pervasive, coordinated protein level changes driven by transcript isoform switching
نویسندگان
چکیده
منابع مشابه
Isoform-level ribosome occupancy estimation guided by transcript abundance with Ribomap
UNLABELLED : Ribosome profiling is a recently developed high-throughput sequencing technique that captures approximately 30 bp long ribosome-protected mRNA fragments during translation. Because of alternative splicing and repetitive sequences, a ribosome-protected read may map to many places in the transcriptome, leading to discarded or arbitrary mappings when standard approaches are used. We p...
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MOTIVATION High-throughput sequencing of RNA in vivo facilitates many applications, not the least of which is the cataloging of variant splice isoforms of protein-coding messenger RNAs. Although many solutions have been proposed for reconstructing putative isoforms from deep sequencing data, these generally take as their substrate the collective alignment structure of RNA-seq reads and ignore t...
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Most human genes have multiple transcription start and polyadenylation sites, as well as alternatively spliced exons. Although such transcript isoform diversity contributes to the differentiation between cell types, the importance of contributions from the different isoform generating processes is unclear. To address this question, we used 798 samples from the Genotype-Tissue Expression (GTEx) ...
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The complexity of mammalian transcriptomes is compounded by alternative splicing which allows one gene to produce multiple transcript isoforms. However, transcriptome comparison has been limited to differential analysis at the gene level instead of the individual transcript isoform level. High-throughput sequencing technologies and high-resolution tiling arrays provide an unprecedented opportun...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2018
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2018.32.1_supplement.651.9